Serum
Is a comprehensive blood test used to help detect celiac disease, an autoimmune condition in which the body reacts abnormally to gluten . measures specific antibodies that indicate whether your immune system is responding to gluten in a harmful way.
Celiac Profile Immune Function Testing
Clinical Information
Patient Information
Test Preparation
Supporting Materials
Aids in the diagnosis of Celiac disease
The Celiac Profile is a blood test that uses widely accepted immunologic biomarkers to aid in the diagnosis of Celiac disease (CD). The markers include Total IgA, Anti-Tissue Transglutaminase IgA (tTG IgA) and IgG (tTG IgG), Anti-Deamidated Gliadin IgA (DGP IgA) and IgG (DGP IgG), and reflex Anti-Endomysial IgA (EMA IgA).
What is Celiac Disease and when should testing be considered?
Celiac disease is defined as an autoimmune enteropathy of the small intestine, caused by exposure to dietary gluten in genetically pre-disposed individuals. In susceptible individuals, gluten ingestion generates an inflammatory reaction predominantly centered in the upper parts of the small intestine. This mucosal injury will eventually reduce the intestinal absorptive area and interfere with uptake of micronutrients.2
Conditions and symptoms associated with Celiac disease
Chronic diarrhea with weight loss
Steatorrhea
Postprandial abdominal pain
Bloating
Malabsorption with nutrient deficiencies (iron, B12, calcium)
Irritable bowel syndrome
Elevated liver enzymes
Cerebellar ataxia
Peripheral neuropathy
Type I Diabetes
Autoimmune hepatitis
Autoimmune thyroiditis
Infertility
Dermatitis herpetiformis
Sjogren syndrome
Addison's disease
Parathyroid disorders
Growth hormone deficiency
Primary biliary cirrhosis
Primary sclerosing cholangitis
Testing should be performed while the patient is still on a gluten-containing diet.1 The exception is follow-up testing for monitoring treatment efficacy.
Ordering the Profile
The Celiac Profile can be ordered as a stand-alone profile or ordered together with other profiles. Often times, clinicians will order several smaller profiles together in order to see a more complete picture of the patient's immune mediated response. Profiles that can be ordered together include:
IgG Foods - 87 foods plus total IgE
IgG Vegetarian - 21 foods plus total IgE
IgG Spices - 24 spices plus total IgE
IgE Food Antibodies - 19 foods plus total IgE
IgE Molds - 14 molds plus total IgE
IgE Inhalants - 14 inhalants specific to 18 North American geographic regions plus total IgE
Celiac Profile - Total IgA, tTG IgA & IgG, DGP IgA & IgG, EMA IgA
What advantage does the Celiac Profile offer compared to other diagnostics?
Intestinal biopsy is considered the gold standard for the diagnosis of Celiac disease. International guidelines suggest that measuring immunologic analytes and genetic markers are favored to increase detection of CD. The European Society for Pediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) introduced a revised guideline for CD in children based on the optimization of antibody assays. According to this guideline, children can be diagnosed with CD without a duodenal biopsy when presenting with suspicious symptoms, a strongly elevated tTG-IgA (>10 confirmed cut-off value), confirmed by a positive EMA-IgA on a separate occasion, and positive genetic testing (HLA-DQ2 and /or HLA-DQ8).5 Genova does not offer the HLA-DQ2/DQ8 genetic markers. Genova offers an interpretive algorithm to aid in assessing likelihood of disease:
How It Works
Getting your GI Effects® test is simple and can be done from the comfort of your
home.
Consult Doctor
Your doctor will discuss your symptoms
and help decide which test is right for
you. Many specimen collections can be
completed from the privacy of your
home.
1
Order Your Collection Kit
Get started with ease—order your collection kit today for quick and hassle-free sampling
2
Collect Samples
Use a calendar to plan for your
collection. Follow instructions carefully
and be sure to add important details
about you and your specimens.
3
Ship to Lab
Ship your specimens using the prepaid
shipping materials provided. Results
are available online.
4
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Health?
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and convenient.
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Immune Funtion