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Urine / Bloodspot / Buccal Swab
Metabolomix+
Advanced Nutritional Insights
Metabolomix+ offers a personalized evaluation of essential nutrients and metabolic function. It helps identify imbalances that impact energy, wellness, and overall health.

Clinical Information
Patient Information
Test Preparation
Supporting Materials
Metabolomix+: A Non-Invasive Personalized Nutritional Assessment
The Metabolomix+ is a unique combination of nutritional tests that provides an analysis of key nutritional biomarkers. A first morning void (FMV) urine collection, with optional add-on bloodspot finger stick and buccal swab, the Metabolomix+ nutritional test is a non-invasive, patient-friendly way to assess the functional need for antioxidants, B-vitamins, minerals, digestive support, fatty acids, and amino acids.
Which patients might benefit from functional nutritional testing?
Common clinical indications for testing include:
Mood disorders
Mitochondrial dysfunction
Fatigue
Chronic stress
Inflammation
Several diseases are associated with abnormal organic acid, amino acid, and fatty acid levels such as depression, anxiety, cardiovascular disease, neurocognitive decline, diabetes, cancer, anorexia, and many others
Testing is not performed in patients under 2 years old. However, Metabolomix+ does include reference ranges and nutrient needs that apply to pediatric patients aged 2 and older
About the Metabolomix+ Profile
The Metabolomix+ Profile report categorizes results into several metabolic areas (see sample report for individual analytes):
Personalized Results Overview and Nutrient Need Overview
Organic Acids (urine)
Functional Imbalance Scores in areas of methylation, toxic exposure, mitochondrial dysfunction, fatty acid imbalances, and oxidative stress
Nutrient Need Overview with recommendations for antioxidants, B-vitamins, minerals, essential fatty acids, GI support, and amino acids
Interpretation-At-A-Glance pages provide nutritional educational support for you and your patient highlighting the function of each nutrient, cause of deficiency, complications of deficiency and food sources of the nutrient
Malabsorption and Bacterial/ Yeast Dysbiosis Markers are metabolites produced by the gastrointestinal microbiome
Cellular Energy & Mitochondrial Metabolites are biomarkers of carbohydrate and fatty acid metabolism, and the citric acid (Kreb's) cycle
Neurotransmitter Metabolites are downstream byproducts of epinephrine, norepinephrine, serotonin and dopamine
Vitamin Markers are specific analytes used to assess functional levels of vitamin cofactors
Toxin & Detoxification Markers relate to certain toxic metabolites and the body's detoxification capacity
Oxalate Markers relate to kidney stone formation, oxidative stress and metabolic dysfunction
Amino Acids (urine)
Malabsorption and Bacterial/ Yeast Dysbiosis Markers are metabolites produced by the gastrointestinal microbiome
Cellular Energy & Mitochondrial Metabolites are biomarkers of carbohydrate and fatty acid metabolism, and the citric acid (Kreb's) cycle
Neurotransmitter Metabolites are downstream byproducts of epinephrine, norepinephrine, serotonin and dopamine
Vitamin Markers are specific analytes used to assess functional levels of vitamin cofactors Toxin & Detoxification Markers relate to certain toxic metabolites and the body's detoxification capacity
Oxalate Markers relate to kidney stone formation, oxidative stress and metabolic dysfunction
+ COMPONENTS
Add-on Essential and Metabolic Fatty Acids Markers (Bloodspot- whole blood)
Omega 3 Fatty Acids are essential for brain function and cardiovascular health and are anti-inflammatory
Omega 6 Fatty Acids are involved in the balance of inflammation
Omega 9 Fatty Acids are important for brain growth, nerve cell myelin, and reducing inflammation Saturated Fatty Acids are involved in liproprotein metabolism and adipose tissue inflammation Monounsaturated Fats include
Omega 7 fats and unhealthy trans fats
Delta-6 Desaturase Activity assesses efficiency of this enzyme to metabolize omega 6's and omega 3's
Cardiovascular Risk includes specific ratios and the Omega 3 Index
Genova's unique approach to nutritional testing begins by assessing our body's biochemical pathways. Marked accumulation of organic acids in urine can signal a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up, or drug effect.
Add-on Comprehensive Urine Element Profile (urine) assesses 18 toxic and 14 mineral elements A
dd-on SNPs (buccal swab) include MTHFR, COMT, TNF-a, and APOE
What is a functional nutritional assessment?
Enzymes that are responsible for metabolizing organic acids are vitamin and mineral dependent. With this, elevations in organic acids can reflect a functional need for these nutrients on a cellular and biochemical level, even despite normal serum levels.11,12,13,14,15 Recommendations for nutrient supplementation based on elevated organic acid results are generated using a literature-based proprietary algorithm.
Traditionally, urinary organic acid assessment has been used in neonatal/pediatric medicine to identify genetic inborn errors of metabolism, with severity depending on the degree and type of error.* In many cases of genetic inborn errors, the enzymatic defect may be compensated for by high doses of specific vitamin and mineral cofactors and/or dietary interventions. Intervention with higher-dose nutrient cofactors may also be effective in cases of decreased enzyme activity due to causes other than frank inborn errors.
Genova's organic acid testing is not intended for the diagnosis of neonatal inborn errors of metabolism.
How It Works
Getting your GI Effects® test is simple and can be done from the comfort of your
home.
Consult Doctor
Your doctor will discuss your symptoms
and help decide which test is right for
you. Many specimen collections can be
completed from the privacy of your
home.
1
Order Your Collection Kit
Get started with ease—order your collection kit today for quick and hassle-free sampling
2
Collect Samples
Use a calendar to plan for your
collection. Follow instructions carefully
and be sure to add important details
about you and your specimens.
3
Ship to Lab
Ship your specimens using the prepaid
shipping materials provided. Results
are available online.
4
Ready to Understand Your Digestive
Health?
Get comprehensive insights into your gut health with the GI Effects® Comprehensive Profile
powered by advanced genomic analysis.
Contact Us
Free shipping • Results in 7-10 days • CLIA-certified lab • Genomic analysis included

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comprehensive health testing
solutions. Professional, reliable,
and convenient.
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