IgE Inhalants – Allergy Test


Identify Indoor Household Allergies and Outdoor Seasonal Allergies

The IgE Inhalants Profile is a blood test that measures IgE antibodies to 16 common indoor and outdoor inhalants specific to 18 North American geographic regions. The profile also includes a total IgE measurement. Testing can help identify whether an allergen is triggering the common symptoms associated with seasonal, pet or mite allergies. These symptoms include sneezing, coughing, itchy and watery eyes, and others. The patient can experience relief with symptom management, and by avoiding ongoing exposure to the identified allergen.

When should testing for IgE Inhalant Antibodies be considered?

Testing for IgE inhalant antibodies is useful for individuals who suspect that they are reacting to an environmental stimulus. Household inhalants include cat and dog dander, cockroach, and mites. Outdoor inhalants include trees, grasses, weeds, and molds, and may bloom or pollinate at various times depending on the region.

An IgE allergic response involves immediate-hypersensitivity to a substance. It is important to test when the patient is symptomatic. Circulating IgE antibodies have a short half-life of around 1-2 days, and will only be produced after exposure to the substance. The presence of circulating antibodies may affect each patient differently. According to the American Academy of Allergy, Asthma, and Immunology, “A key message is that a positive allergy test result (skin or blood) indicates only the presence of allergen-specific IgE (called sensitization). It does not necessarily mean clinical allergy (i.e., allergic symptoms with exposure).”1 Therefore, test results should always be viewed in the context of the overall clinical picture.

Symptoms and conditions associated with IgE inhalant allergies

  • Stuffy or itchy nose, sneezing, rhinitis or sinusitis
  • Itchy, teary eyes, conjunctivitis
  • Cough, shortness of breath, wheezing, asthma
  • Skin rash or hives

Ordering the test

The IgE Inhalants Profile can be ordered as a stand-alone test or bundled with other profiles. Often times, clinicians will bundle several smaller profiles in order to see a more complete picture of the patient’s immune-mediated response. Profiles that can be bundled include:

Profile Includes
IgG Foods 87 foods plus total IgE
IgG Vegetarian 21 foods plus total IgE
IgG Spices 23 spices plus total IgE
IgE Foods 19 foods plus total IgE
IgE Molds 15 molds plus total IgE
IgE Inhalants 16 inhalants specific to 18 North American geographic regions plus total IgE
Celiac and Gluten Sensitivity Total IgA, tTG IgA, DGP IgA, EMA IgA, Anti-Gliadin IgG & IgA


What advantage does the IgE Inhalants Profile offer compared to other diagnostics?

Identifying airborne allergens can be difficult and testing serum allergen-specific IgE antibodies is helpful. Allergen-specific serum IgE testing does not involve introducing an allergen in order to test. Instead, already circulating antibodies are measured, however, the patient must have been exposed to the allergen in the days leading up to testing in order to detect antibodies.

A skin-prick test involves the injection of an allergen on the skin then observation for a reaction. Serum testing can be especially useful when skin-prick tests cannot be performed for example, due to extensive dermatitis or dermatographism, when antihistamines cannot be discontinued, or those with a history of anaphylactic reaction.2

Genova’s Methodology

IgE Antibody Testing

Genova utilizes the FDA-cleared Siemans Immulite® 2000 Total IgE and 3gAllergy Specific IgE Universal Kits. Immulite® 2000 Total IgE is a solid-phase Chemiluminescent assay. Immulite® 3gAllergy Specific IgE is a solid phase, two-step, chemiluminescent immunoassay that exploits liquid phase kinetics in a bead format. Siemens proprietary liquid allergens are the key to making IMMULITE® 2000 Immunoassay allergy tests sensitive, specific, and reliable. The soluble polymer/copolymer support for the allergens increases the number of binding sites and their accessibility to allergen-specific IgE antibodies. Enzyme-enhanced chemiluminescent signal detection provides increased sensitivity and the proprietary wash technique enhances specificity.

What can clinicians and patients expect from IgE Inhalant testing?

In general, clinical management of the patient with inhalant allergies involves medicines, allergy shots and/or supplements to manage symptoms, as well as cleaning and preventing further exposure to the identified allergen in the household. HEPA filters and regular cleaning practices may help to reduce the allergen burden.

Analyte List
Alder Tree- IgE
Australian Pine Tree- IgE
Bahia Grass- IgE
Bermuda Grass- IgE
Birch Tree- IgE
Brome Grass- IgE
Canary Grass- IgE
Cat dander- IgE
Cocklebur- IgE
Cockroach- IgE
Common Ragweed- IgE
Cottonwood Tree- IgE
Cultivated Oat Grass- IgE
Dandelion- IgE
Dog dander- IgE
Elm Tree- IgE
English Plantain- IgE
Eucalyptus Tree- IgE
Giant Ragweed- IgE
Johnson Grass- IgE
June Grass (Kentucky Blue)- IgE
Lamb's quarters- IgE
Maple Tree- IgE
Mesquite Tree- IgE
Mite Generic- IgE
Mold Generic- IgE
Mountain Cedar Tree- IgE
Nettle- IgE
Oak Tree- IgE
Olive Tree- IgE
Orchard Grass- IgE
Pecan Tree- IgE
Perennial Rye Grass- IgE
Red Top- IgE
Rough Marsh Elder- IgE
Rough Pigweed- IgE
Russian Thistle- IgE
Scale- IgE
Sweet Vernal Grass- IgE
Timothy Grass- IgE
Total IgE
Walnut Tree- IgE
Western Ragweed- IgE
White Mulberry Tree- IgE
CPT Codes
Alder Tree- IgE 86003
Australian Pine Tree- IgE 86003
Bahia Grass- IgE 86003
Bermuda Grass- IgE 86003
Birch Tree- IgE 86003
Brome Grass- IgE 86003
Canary Grass- IgE 86003
Cat dander- IgE 86003
Cocklebur- IgE 86003
Cockroach- IgE 86003
Common Ragweed- IgE 86003
Cottonwood Tree- IgE 86003
Cultivated Oat Grass- IgE 86003
Dandelion- IgE 86003
Dog dander- IgE 86003
Elm Tree- IgE 86003
English Plantain- IgE 86003
Eucalyptus Tree- IgE 86003
Giant Ragweed- IgE 86003
Johnson Grass- IgE 86003
June Grass (Kentucky Blue)- IgE 86003
Lamb's quarters- IgE 86003
Maple Tree- IgE 86003
Mesquite Tree- IgE 86003
Mite Generic- IgE 86003
Mold Generic- IgE 86003
Mountain Cedar Tree- IgE 86003
Nettle- IgE 86003
Oak Tree- IgE 86003
Olive Tree- IgE 86003
Orchard Grass- IgE 86003
Pecan Tree- IgE 86003
Perennial Rye Grass- IgE 86003
Red Top- IgE 86003
Rough Marsh Elder- IgE 86003
Rough Pigweed- IgE 86003
Russian Thistle- IgE 86003
Scale- IgE 86003
Sweet Vernal Grass- IgE 86003
Timothy Grass- IgE 86003
Total IgE 82785
Walnut Tree- IgE 86003
Western Ragweed- IgE 86003
White Mulberry Tree- IgE 86003
Specimen Requirements
3ml serum in transfer tube (frozen)


Additional Resources